diff --git a/features/domains/default.xml b/features/domains/default.xml
index 52247fb98f943863a4ed501b3ce0d4be7010e31b..2c99931dd6bfd9af4005e5a1862336833f4d8a5f 100644
--- a/features/domains/default.xml
+++ b/features/domains/default.xml
@@ -3,7 +3,7 @@
   <currentMemory unit='KiB'>2097152</currentMemory>
   <vcpu>2</vcpu>
   <os>
-    <type arch='x86_64' machine='pc-q35-2.8'>hvm</type>
+    <type arch='x86_64' machine='pc-q35-5.0'>hvm</type>
     <boot dev='cdrom'/>
   </os>
   <features>
diff --git a/features/scripts/opencv_match_template.py b/features/scripts/opencv_match_template.py
index 7047fb73d5a1ef40afdacf57ef207a81ea2bbb3a..e544e1a7265ea35f884dc05bd04e975edbab3a42 100755
--- a/features/scripts/opencv_match_template.py
+++ b/features/scripts/opencv_match_template.py
@@ -1,9 +1,5 @@
 #!/usr/bin/env python3
 
-# XXX:Buster: when we drop support for Stretch we can remove this
-# import.
-from __future__ import print_function
-
 import cv2
 import os
 import sys
diff --git a/features/step_definitions/erase_memory.rb b/features/step_definitions/erase_memory.rb
index e19ec252af478b2cfeb69dd545fb80947aa606e7..5d5f5d3f883689c55085c9d28c350a74ab3eaab1 100644
--- a/features/step_definitions/erase_memory.rb
+++ b/features/step_definitions/erase_memory.rb
@@ -226,10 +226,8 @@ When /^I fill a (\d+) MiB file with a known pattern on the (persistent|root) fil
   end
   # Note that `yes` prints its own newline, so we have to skip it in
   # `pattern` below.
-  # XXX:Stretch: once we drop support < Buster we can improve the
-  # expression below to `pattern[..-2]`.
   $vm.execute_successfully(
-    "yes #{pattern[0, pattern.length - 1]} | " \
+    "yes #{pattern[0..-2]} | " \
     "dd of=#{dest_file} bs=#{pattern.size} count=#{pattern_nb}"
   )
 end
diff --git a/features/step_definitions/mac_spoofing.rb b/features/step_definitions/mac_spoofing.rb
index c8cc558ab67f8ed09bdb649df478312b96b49510..a9a24fbfe3e44cddb2bd2a0a0731ae5468c36ec6 100644
--- a/features/step_definitions/mac_spoofing.rb
+++ b/features/step_definitions/mac_spoofing.rb
@@ -104,14 +104,7 @@ end
 
 When /^I hotplug a network device( and wait for it to be initialized)?$/ do |wait|
   initial_nr_nics = wait ? all_ethernet_nics.size : nil
-  # XXX:Buster: when we stop supporting the test suite on Stretch
-  # hosts, let's remove this workaround related to #14819 and just
-  # settle on a device that works on all supported platforms.
-  device = if cmd_helper('lsb_release --short --codename').chomp == 'stretch'
-             'virtio'
-           else
-             'pcnet'
-           end
+  device = 'pcnet'
   debug_log("Hotplugging a '#{device}' network device")
   xml = <<-XML
     <interface type='network'>
diff --git a/features/step_definitions/pidgin.rb b/features/step_definitions/pidgin.rb
index d84b24fd607e0363a72223fa527072f2a8751948..f9497a20144abe5d10332e796a78679dc0c4b092 100644
--- a/features/step_definitions/pidgin.rb
+++ b/features/step_definitions/pidgin.rb
@@ -113,9 +113,7 @@ Given /^my XMPP friend goes online( and joins the multi-user chat)?$/ do |join_c
     account['username'] + '@' + account['domain'],
     account['password'],
     account['otr_key'],
-    # XXX:Buster: once we stop supporting running our test suite on Stretch,
-    # replace this with: **(bot_opts.transform_keys(&:to_sym))
-    **(bot_opts.each_with_object({}) { |(k, v), a| a[k.to_sym] = v })
+    **(bot_opts.transform_keys(&:to_sym))
   )
   @chatbot.start
   add_after_scenario_hook { @chatbot.stop }
diff --git a/features/step_definitions/totem.rb b/features/step_definitions/totem.rb
index a5a87d4e4a23c92878469aea6a082c64165434b3..0a644d096d2192a56bd4166e5fde0344d31a8d9f 100644
--- a/features/step_definitions/totem.rb
+++ b/features/step_definitions/totem.rb
@@ -5,7 +5,7 @@ Given /^I create sample videos$/ do
   @video_dir_on_host = "#{$config['TMPDIR']}/video_dir"
   FileUtils.mkdir_p(@video_dir_on_host)
   add_after_scenario_hook { FileUtils.rm_r(@video_dir_on_host) }
-  fatal_system("#{ffmpeg} -loop 1 -t 30 -f image2 " \
+  fatal_system('ffmpeg -loop 1 -t 30 -f image2 ' \
                "-i 'features/images/USBTailsLogo.png' " \
                '-an -vcodec libx264 -y ' \
                '-filter:v "crop=in_w-mod(in_w\,2):in_h-mod(in_h\,2)" ' \
diff --git a/features/support/helpers/dogtail.rb b/features/support/helpers/dogtail.rb
index a112fb9138bbe829f286050f2d9bb7105d44f03f..0c7aa6b61e423879e8818fcb8652ce8dedc20aa9 100644
--- a/features/support/helpers/dogtail.rb
+++ b/features/support/helpers/dogtail.rb
@@ -117,8 +117,7 @@ module Dogtail
         'False'
       elsif value.class == String
         "'#{value}'"
-      # XXX:Buster: drop the Fixnum line once we stop supporting Stretch
-      elsif [Fixnum, Integer, Float].include?(value.class) # rubocop:disable Lint/UnifiedInteger
+      elsif [Integer, Float].include?(value.class)
         v.to_s
       else
         raise "#{self.class.name} does not know how to handle argument type " \
diff --git a/features/support/helpers/misc_helpers.rb b/features/support/helpers/misc_helpers.rb
index b44d4b2aabf413fe6f9d9cb14cf77ffed192f252..cf451dbafdd502d10048a7a253be468937825006 100644
--- a/features/support/helpers/misc_helpers.rb
+++ b/features/support/helpers/misc_helpers.rb
@@ -35,14 +35,7 @@ end
 
 def time_delta(start_time, now)
   elapsed = now - start_time
-  # XXX: Drop this version check when we drop support for running the test suite
-  # on Debian Stretch.
-  if Gem::Version.new(RUBY_VERSION) < Gem::Version.new('2.4')
-    format('%<elapsed>.2f', elapsed: elapsed)
-      .chomp('.00').chomp('.0').chomp('0')
-  else
-    elapsed.ceil(2)
-  end
+  elapsed.ceil(2)
 end
 
 # Call block (ignoring any exceptions it may throw) repeatedly with
@@ -394,8 +387,6 @@ def dbus_send_get_shellcommand(service, object_path, method, *args, **opts)
   opts ||= {}
   ruby_type_to_dbus_type = {
     String  => 'string',
-    # XXX:Buster: drop the Fixnum line once we stop supporting Stretch
-    Fixnum  => 'int32', # rubocop:disable Lint/UnifiedInteger
     Integer => 'int32',
   }
   typed_args = args.map do |arg|
@@ -426,14 +417,6 @@ def dbus_send(*args, **opts)
   dbus_send_ret_conv(ret)
 end
 
-def ffmpeg
-  if cmd_helper('lsb_release --short --codename').chomp == 'stretch'
-    'avconv'
-  else
-    'ffmpeg'
-  end
-end
-
 # This is IO.popen() that ensures that we wait() for the subprocess to
 # finish. Please use this instead IO.popen() when running a subprocess
 # inside a try_for() or other Timeout::timeout() block!
diff --git a/features/support/helpers/opencv.rb b/features/support/helpers/opencv.rb
index 5e79876d7fa5317884e6dcb099ff5c2b62aa1384..0eabfba540a4cfc49ccc360b7801952be9579a86 100644
--- a/features/support/helpers/opencv.rb
+++ b/features/support/helpers/opencv.rb
@@ -4,12 +4,6 @@ class OpenCVInternalError < StandardError
 end
 
 module OpenCV
-  @python = if cmd_helper('lsb_release --short --codename').chomp == 'stretch'
-              'python2.7'
-            else
-              'python3'
-            end
-
   def self.matchTemplate(image, screen, sensitivity, show_match)
     assert(sensitivity < 1.0)
     # Do a deep-copy so we don't mess up the outer environment
@@ -20,7 +14,7 @@ module OpenCV
       env['DISPLAY'] = ENV['USER_DISPLAY']
     end
     p = popen_wait(
-      [env, @python, "#{GIT_DIR}/features/scripts/opencv_match_template.py",
+      [env, 'python3', "#{GIT_DIR}/features/scripts/opencv_match_template.py",
        screen, image, sensitivity.to_s, show_match.to_s,],
       err: [:child, :out]
     )
diff --git a/features/support/hooks.rb b/features/support/hooks.rb
index 5389090b118e54466846ba7406974f96cf1b412a..d50fcf0859afa2f14f81f62ba087db669798471b 100644
--- a/features/support/hooks.rb
+++ b/features/support/hooks.rb
@@ -224,7 +224,7 @@ Before('@product') do |scenario|
   if $config['CAPTURE']
     video_name = sanitize_filename("#{scenario.name}.mkv")
     @video_path = "#{ARTIFACTS_DIR}/#{video_name}"
-    capture = IO.popen([ffmpeg,
+    capture = IO.popen(['ffmpeg',
                         '-f', 'x11grab',
                         '-s', '1024x768',
                         '-r', '15',
diff --git a/run_test_suite b/run_test_suite
index 38ebb945b89e1e031d3d156c7ff17de01cd6cd96..dfaf621577e4c29237ff4a32dceda1fd9893b651 100755
--- a/run_test_suite
+++ b/run_test_suite
@@ -10,6 +10,7 @@ GENERAL_DEPENDENCIES="
 cucumber
 devscripts
 dnsmasq-base
+ffmpeg
 gawk
 git
 i18nspector
@@ -23,6 +24,8 @@ obfs4proxy
 openssh-server
 ovmf
 pry
+python3-opencv
+python3-pil
 python-jabberbot
 python-potr
 qemu-system-x86
@@ -44,20 +47,6 @@ xdotool
 xvfb
 "
 
-if [ "$(lsb_release --short --codename)" = "stretch" ]; then
-    GENERAL_DEPENDENCIES="${GENERAL_DEPENDENCIES}
-libav-tools
-python-opencv
-python-pil
-"
-else
-    GENERAL_DEPENDENCIES="${GENERAL_DEPENDENCIES}
-ffmpeg
-python3-opencv
-python3-pil
-"
-fi
-
 usage() {
     echo "Usage: $NAME [OPTION]... [--] [CUCUMBER_ARGS]...
 Sets up an appropriate environment and invokes cucumber. Note that this script
diff --git a/wiki/src/contribute/release_process/test/setup.mdwn b/wiki/src/contribute/release_process/test/setup.mdwn
index d2dd800a9b8a550cd22a6296f82c74bb105b79c7..bec91fea790649e53bc150c28ca07edcc401294e 100644
--- a/wiki/src/contribute/release_process/test/setup.mdwn
+++ b/wiki/src/contribute/release_process/test/setup.mdwn
@@ -18,7 +18,7 @@ Operating system
 </p>
 </div>
 
-If you usually run another operating system than Debian Stretch,
+If you usually run another operating system than Debian
 Buster, Bullseye or Sid, then you need to:
 
 1. Enable nested virtualization on your host system.
@@ -46,7 +46,7 @@ To install the dependencies on our test suite:
 2. Install the following packages:
 
         dist=$(lsb_release --short --codename)
-        if [ "${dist}" != stretch -o "${dist}" != buster ]; then
+        if [ "${dist}" != buster ]; then
             # For python-jabberbot and python-potr, that were removed after Buster
             echo 'deb http://ftp.us.debian.org/debian/ buster main' \
                 | sudo tee /etc/apt/sources.list.d/buster.list
@@ -103,17 +103,9 @@ To install the dependencies on our test suite:
             x264 \
             xdotool \
             xvfb \
-            $(
-                if [ "${dist}" = stretch ]; then
-                    echo "libav-tools
-                          python-opencv
-                          python-pil"
-                else
-                    echo "ffmpeg
-                          python3-opencv
-                          python3-pil"
-                fi
-            ) \
+            ffmpeg \
+            python3-opencv \
+            python3-pil \
             && \
         sudo service libvirtd restart
 
@@ -145,23 +137,9 @@ If you have AppArmor enabled:
   to `/etc/apparmor.d/libvirt/TEMPLATE.qemu`, in the
   `profile LIBVIRT_TEMPLATE` section; then delete
   `/etc/apparmor.d/libvirt/libvirt-*` and restart the test suite.
-  On Debian Stretch, if you use a custom `TMPDIR` to run the test suite,
+  If you use a custom `TMPDIR` to run the test suite,
   replace `/tmp/TailsToaster` with the value of that `$TMPDIR`.
 
-Patched QEMU
-------------
-
-Due to [[!tails_ticket 12142]]
-aka. [[!debbug 851694]], any test scenario that creates a persistent
-volume will fail. To work around this problem, rebuild [[!debpts
-qemu]] locally with the upstream fix applied. For example, the `qemu`
-source package in this APT suite has the fix:
-
-        deb-src http://deb.tails.boum.org/ isotester-stretch main
-
-This problem does not affect host systems that run Debian Buster
-or newer.
-
 Special use cases
 =================